4 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A nanobody-based molecular toolkit provides new mechanistic insight into clathrin-coat initiation

    Linton M Traub
    New intracellularly-expressed llama anti-EPS15 nanobodies reveal that pioneer clathrin-coat components function upstream of AP-2 clathrin adaptor deposition at the plasma membrane.
    1. Cell Biology

    Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

    Valentina Galli et al.
    Uncoupling of dynamin polymerization and GTPase activity can be induced with dynamin, which allows in vivo visualization of its activity at endocytic pits.
    1. Cell Biology
    2. Immunology and Inflammation

    NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

    Sandrine Moutel et al.
    A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Sculpting ion channel functional expression with engineered ubiquitin ligases

    Scott A Kanner et al.
    Engineered E3 ubiquitin ligases are utilized to elucidate mechanisms underlying ubiquitin regulation of membrane proteins, and to achieve robust post-translational functional knockdown of ion channels.

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