The discovery of a fluorescent protein that can be rapidly switched between long-lived ‘on’ and ‘off’ states will lead to a new generation of super-resolution imaging experiments on living cells.

A deubiquitinase antagonizes the activity of an associated E3 ligase to prevent uncontrolled ubiquitination of a degradation machinery protein and thus maintain its functionality in protein quality control at the endoplasmic reticulum.

A pathway directed by the KRAS oncoprotein leads to aberrant hypermethylation and transcriptional silencing of many genes including tumor suppressors, thereby promoting tumor development.

Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.

Genetic mouse models and human cell lines show that Musashi proteins promote an epithelial/luminal state and inhibit epithelial–mesenchymal transition (EMT), and genome-wide maps of translational regulatory targets connect Musashi proteins to an epithelial alternative splicing program and to the regulation of EMT.

Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.

The protein CpoB regulates PBP1B activity in response to the Tol energy state, which facilitates feedback and synchronicity between envelope constriction processes during Gram-negative bacterial cell division.

Wss1 is both a metalloprotease and SUMO ligase found in association with Cdc48 and Doa1 and accumulating in the vacuole upon DNA damage.

The dynamic homeostasis of the planarian epidermis serves as an experimental paradigm to study stem cell dynamics and post-mitotic specification of diverse functional cell fates.

Transcription factors of the ETS family govern a cohort of key cancer-associated regulators of malignancy in squamous cell carcinomas.