1,620 results found
    1. Immunology and Inflammation

    A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

    Shigetoshi Yokoyama et al.
    A novel pathway was discovered for cellular uptake of LPS through secretory protein secretoglobin3A2 and a receptor syndecan-1, causing activation of non-canonical inflammasome pathway leading to pyroptosis of cancer cells.
    1. Cell Biology

    MiniCORVET is a Vps8-containing early endosomal tether in Drosophila

    Péter Lőrincz et al.
    An unconventional endosomal tether in Drosophila melanogaster only has four of the six subunits found in the yeast complex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Architecture and RNA binding of the human negative elongation factor

    Seychelle M Vos et al.
    The structural architecture of the 4-subunit, RNA-binding human negative elongation factor NELF is derived by a combination of X-ray crystallography and protein crosslinking.
    1. Cell Biology
    2. Developmental Biology

    Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt

    Péter Lőrincz et al.
    Recruitment of HOPS tethering complex to target membranes to promote vesicle fusions requires proper complex assembly and specific small GTPases, and HOPS is not transformed from the related miniCORVET complex.
    1. Microbiology and Infectious Disease

    Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

    Siyuan Ding et al.
    Rotavirus infection induces phosphorylation and proteasomal degradation of MAVS to suppress host antiviral interferon signaling.
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes

    Luisa CS Antunes et al.
    Phylogenomics provides support for the Gram-positive type of bacterial cell envelope being a derived character that arose independently multiple times through loss of an ancestral outer membrane.
    1. Structural Biology and Molecular Biophysics

    Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

    Timothy Grant, Nikolaus Grigorieff
    The resolution of electron cryo-microscopy can be improved by using optimal exposure values to filter video frames.
    1. Microbiology and Infectious Disease

    Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

    Myra Hosmillo et al.
    A key cellular stress granule protein, G3BP1, is critical for efficient norovirus infection, representing the first pan-norovirus, pro-viral factor identified to date.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Biofilms: Flipping the switch

    Xavier Pierrat, Alexandre Persat
    A structural switch controls the architecture of Vibrio cholerae biofilms by mediating the interactions between two matrix components.
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