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    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog

    Antoine Hocher et al.
    In Thermoplasma acidophilum, an archaeon without histones, a DNA-binding protein acquired from bacteria via horizontal gene transfer mediates histone-like chromatin architecture.
    1. Cell Biology

    Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

    Yajuan Guo et al.
    Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
    1. Cell Biology
    2. Neuroscience

    Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor

    Corinne L Pender, H Robert Horvitz
    The hypoxia-inducible factor HIF drives transcription of the gene cyp-36A1, which encodes a cytochrome P450 enzyme that acts via a putative intercellular signal to regulate the nuclear receptor NHR-46 and consequently stress resistance and behavior.
    1. Stem Cells and Regenerative Medicine

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Immunology and Inflammation

    CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

    Xiaomei Yuan et al.
    Tissue-resident macrophages sense environmental cues and regulate adaptive immunity via an immune checkpoint molecule CRIg.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways

    Jennie R Sims et al.
    The OSM-9 TRPV channel is differentially regulated due to developmental programming via modulation by TGF-β signaling, endogenous RNAi and chromatin remodeling pathways.
    1. Developmental Biology

    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

    Man Chu et al.
    Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
    1. Biochemistry and Chemical Biology

    Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response

    Xu Zhang et al.
    The RNA-binding protein, Zfp36, which is critical for resolving inflammation, inhibits the production of proinflammatory cytokines via modulation of the cytoplasmic poly(A)-binding protein.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Atrophin controls developmental signaling pathways via interactions with Trithorax-like

    Kelvin Yeung et al.
    ChIP-seq and phenotypic analyses reveal Atrophin from Drosophila directly regulates Notch and Dpp signaling components, and engrailed gene expression, via interactions with GAGA Factor.
    1. Cell Biology

    Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae

    Galina V Beznoussenko et al.
    The soluble cargo protein albumin traverses the Golgi stack at much faster rates than procollagen aggregates, by diffusion via intercisternal continuities.