2,181 results found
    1. Cell Biology
    2. Cancer Biology

    SPOP mutation leads to genomic instability in prostate cancer

    Gunther Boysen et al.
    SPOP mutations underlie a novel, genomically unstable subclass of prostate cancer by altering DNA repair.
    1. Epidemiology and Global Health
    2. Plant Biology

    Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

    Elizabeth A Savory et al.
    The horizontal acquisition of virulence plasmids is potentiated by production practices in plant nurseries and is sufficient to transition Rhodococcus from being beneficial to being pathogenic.
    1. Chromosomes and Gene Expression

    Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

    Jeffrey M Alexander et al.
    Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Host-associated microbe PCR (hamPCR) enables convenient measurement of both microbial load and community composition

    Derek S Lundberg et al.
    hamPCR is a cost-effective and transformative amplicon sequencing strategy to describe microbiota composition and measure its overall abundance, applicable to all samples in which host and microbial DNA are co-extracted.
    1. Microbiology and Infectious Disease

    Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans

    Linxia Liu et al.
    Meiosis and differentiation of basidium, a defining sexual structure of the phylum Basidiomycota, are genetically integrated by a shared regulatory program to ensure the formation of infectious meiospores in Cryptococcus neoformans.
    1. Immunology and Inflammation

    Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

    Jakob Malsy et al.
    Characterization of the effects of complement- and inflammasome-mediated inflammation on choroidal neovascularization in a mouse model of neovascular age-related macular degeneration suggests synergistic benefits from targeting both forms of inflammation.
    1. Ecology
    2. Microbiology and Infectious Disease

    Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes

    Daniel Dar et al.
    Computational approach quantifies the abundance of phenazine-antibiotic producing and biodegrading bacteria in diverse soil and plant-associated habitats.
  1. Interview: Tying everything together

    Having the freedom to follow her curiosity has enabled Yael Artzy-Randrup to explore the boundaries of ecology and evolution.
  2. Icon linking document, data and code

    Reproducible Document Stack – supporting the next-generation research article

    With Substance and Stencila, we are developing the technology required to publish computationally reproducible research articles online.
  3. Life story: FM

    Getting your priorities straight will help you to achieve your goals.

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