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    1. Neuroscience

    Cortical magnification in human visual cortex parallels task performance around the visual field

    Noah C Benson et al.
    In humans, the surface area of early visual cortex across polar angle is distributed in a pattern that correlates strongly with radial asymmetries in behavioral performance on visual tasks.
    1. Cell Biology

    Prickle isoforms determine handedness of helical morphogenesis

    Bomsoo Cho et al.
    The Pkpk and Pksple isoforms of the Prickle protein determine right- or left-handed bristle morphogenesis by coupling Frizzled/Vang signaling to the Fat/Dachsous PCP directional signal in opposite directions.
    1. Neuroscience

    Decision and navigation in mouse parietal cortex

    Michael Krumin et al.
    When mice use vision to choose their trajectories, a large fraction of parietal cortex activity can be precisely predicted from navigational attributes such as spatial position and heading.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin V executes steps of variable length via structurally constrained diffusion

    David Hathcock et al.
    A theoretical model comprehensively describes the stepping dynamics of the motor protein myosin V, unraveling the significance of a recently discovered structural constraint on the angle between its lever arms.
    1. Cell Biology
    2. Developmental Biology

    Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes

    Sara N Stahley et al.
    Planar cell polarity protein Celsr1 clusters into punctate assemblies through lateral cis-interactions to function as an organizer of intercellular Frizzled6 and Vangl2 asymmetry.
    1. Neuroscience

    Visual field map clusters in human frontoparietal cortex

    Wayne E Mackey et al.
    Topographic maps of space in frontal and parietal cortex are organized into clusters, similar to visual cortex, where multiple maps of polar angle share a confluent fovea.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.
    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

    Benjamin G Butt et al.
    A conserved viral protein complex that promotes membrane wrapping of nascent herpesvirus particles shows structural similarity to cellular membrane-remodelling proteins, suggesting functional mimicry.
    1. Neuroscience

    Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer’s disease related oligomers

    Tobias Lieblein et al.
    Monitoring the formation of two distinct arrangements in early amyloid-ß aggregation by mass spectrometry and ion mobility allows determination of the effect of potential drug candidates.
    1. Cell Biology
    2. Developmental Biology

    Spatial and temporal analysis of PCP protein dynamics during neural tube closure

    Mitchell T Butler, John B Wallingford
    Planar cell polarity proteins display dynamic spatial and temporal patterns of enrichment that tightly correlate with myosin-dependent cell behaviors during neural tube closure.