98 results found
    1. Neuroscience

    Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons

    Julio D Perez et al.
    Single somata and dendrites of individual rat neurons were laser-captured and sequenced to discover and compare the subcellular transcriptomes, identifying over 4000 mRNAs in GABAergic dendrites.
    1. Neuroscience

    Human complex exploration strategies are enriched by noradrenaline-modulated heuristics

    Magda Dubois et al.
    Humans supplement complex, resource-demanding strategies with simple heuristics for solving the exploration-exploitation dilemma, and noradrenaline functioning controls their utilisation.
    1. Microbiology and Infectious Disease

    Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

    Michaela Gregorova et al.
    Post-acute or long-COVID is associated with bystander T-cell activation and a recurring antimicrobial resistant, bacterial ventilator-associated pneumonia.
    1. Cell Biology
    2. Medicine

    Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

    Zhonghao Deng et al.
    Def6 functions as a novel immunoregulator in bone cells via endogenous type-I interferon response to regulate bone remodeling.
    1. Neuroscience

    Impaired adaptation of learning to contingency volatility in internalizing psychopathology

    Christopher Gagne et al.
    Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.
    1. Evolutionary Biology

    Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons

    Bastien Saint-Leandre et al.
    Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in Drosophila.
    1. Medicine

    Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

    Matthew D Keefe et al.
    Neurological pathology and chronic activation of the induced stress response are caused by expression of a truncated EIF2B5 in vanishing white matter disease.
    1. Physics of Living Systems

    Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility

    Elizabeth Eck et al.
    Confronting different models of chromatin accessibility with temporally resolved transcription profiles favors a scenario where transcription factors actively, rather than passively, drive chromatin from the inaccessible to the accessible state.
    1. Chromosomes and Gene Expression

    Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation

    Steven Henikoff et al.
    A simple modification of CUT&Tag chromatin profiling method provides high-quality chromatin accessibility maps and indicates that 'open' chromatin results from a transcription-coupled process at promoters and enhancers.
    1. Developmental Biology

    The Drosophila Individual Activity Monitoring and Detection System (DIAMonDS)

    Ki-Hyeon Seong et al.
    The DIAMonDS can automatically and sequentially identify time points of multiple life cycle events such as pupariation, eclosion, and death in individual flies at high temporal resolution and large scale.

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