Increasing levels of the growth factor Vegfa disrupt blood vessel branching morphogenesis and drive diameter increase by synchronizing Notch signalling fluctuations between endothelial cells.
Sarvenaz Sarabipour, Kurt Ballmer-Hofer, Kalina Hristova
A receptor for vascular endothelial growth factor forms dimers in the absence of its ligand, and ligand-binding leads to structural changes that result in increased kinase phosphorylation.
Interactions between Neuropilin-1 and VEGFR2, rather than VEGF-Neuropilin-1 binding, underlie Neuropilin-1's critical function in VEGF-mediated vascular development.
Arpan C Ghosh, Sudhir Gopal Tattikota ... Norbert Perrimon
A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.
The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
Kazuhide S Okuda, Mikaela S Keyser ... Benjamin M Hogan
Live-imaging of a transgenic reporter of vascular Erk signalling in zebrafish reveals sequential signalling mechanisms during the initiation of regeneration in wounded blood vessels.
Genetic studies reveal a role for Yap1 in lymphatic endothelial progenitor cell sprouting and proliferation during early zebrafish lymphatic vascular development.
Melina Hußmann, Dörte Schulte ... Stefan Schulte-Merker
Tie1 is a binding partner for Svep1 in zebrafish and humans, and both genes (but not Tie2) are required during zebrafish lymphangiogenesis especially for the facial lymphatics, which in part develop independent of Vegfc.
