119 results found
    1. Developmental Biology
    2. Neuroscience

    Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    Subhash Kulkarni, Monalee Saha ... Pankaj Jay Pasricha
    Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Neuroscience

    Activity-dependent lateral inhibition enables the synchronization of olfactory bulb projection neurons

    Tal Dalal, Rafi Haddad
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Evolutionary Biology

    On the nature of the earliest known lifeforms

    Dheeraj Kanaparthi, Frances Westall ... Tillmann Lueders
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape

    Fred D Mast, Peter C Fridy ... Michael P Rout
    A large repertoire of nanobodies that target discrete regions of SARS-CoV-2 spike shows effective neutralization against variants of concern with many pairwise combinations resistant to escape and demonstrating synergistic neutralization activities.
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven, Alyssa Bravin ... Benjamin L de Bivort
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging

    Siqi Wang, Danyue Dong ... Zefeng Wang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

    Liyun Zhang, Conan Chen ... Jeff S Mumm
    Using a cross-species phenotypic drug discovery pipeline, compounds promoting rod photoreceptor survival in zebrafish and mouse models of retinitis pigmentosa were identified, evidence of additive effects of paired compounds and inhibition of PARP-dependent cell death suggest novel therapeutic strategies.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

    Zhi Yang Tan, Shujun Cai ... Lu Gan
    Nucleosomes inside of baker’s yeast cells largely do not resemble those found in test tubes.
    1. Evolutionary Biology

    Destructive disinfection of infected brood prevents systemic disease spread in ant colonies

    Christopher D Pull, Line V Ugelvig ... Sylvia Cremer
    Upon detecting a fatal infection using chemical cues, ants puncture the cuticle of sick brood and inject antimicrobial poison that disrupts the pathogen's life cycle and prevents it from reproducing, thus protecting the colony from disease.

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