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    1. Genes and Chromosomes

    Rapid DNA replication origin licensing protects stem cell pluripotency

    Jacob Peter Matson et al.
    The unique cell cycle variations of pluripotent stem cells ensures that the first step in DNA replication is particularly fast and this rapid rate, in turn, restrains early differentiation.
    1. Neuroscience

    Paradoxical response reversal of top-down modulation in cortical circuits with three interneuron types

    Luis Carlos Garcia del Molino et al.
    Computational simulations and mathematical derivations reveal why the response of neural populations to external modulation is sometimes reversed with respect to what intuition would lead to believe in cortical circuits with multiple types of inhibitory neurons.
    1. Neuroscience

    Local processing in neurites of VGluT3-expressing amacrine cells differentially organizes visual information

    Jen-Chun Hsiang et al.
    Neurite arbors of VGluT3-expressing amacrine cells (VG3-ACs) process visual information locally uniformly detecting object motion while varying in contrast preferences; and in spite of extensive overlap between arbors of neighboring cells population activity in the VG3-AC plexus encodes stimulus positions with subcellular precision.
    1. Biochemistry
    2. Cell Biology

    CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

    Dongqing Pan et al.
    The stoichiometry and mechanism of interactions of the Mis18 complex with M18BP1 was analysed to unveil the molecular basis of new CENP-A deposition during the G1 phase of the cell cycle.
    1. Cancer Biology
    2. Cell Biology

    LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells

    Limian Cao et al.
    A c-Myc-transcribed long noncoding RNA namely LAST (LncRNA-assisted stabilization of transcripts) collaborates with a cellular factor CNBP to promote the stability of CCND1/cyclin D1 mRNA post-transcriptionally, ensuring the proper G1/Sphase transition of the cell cycle.
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone et al.
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Cell Biology

    Reliable cell cycle commitment in budding yeast is ensured by signal integration

    Xili Liu et al.
    The decision to commit to cell division-the Start transition-in budding yeast is governed by time integration of G1 cyclin-CDK activity by the transcription factor Whi5.
    1. Neuroscience

    An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina

    Tahnbee Kim et al.
    The mouse visual system is able to detect small moving objects due to the activity of VG3-amacrine cells, an unusual type of modulatory cell that uses the transmitter glutamate to activate retinal output cells.
    1. Biochemistry
    2. Cell Biology

    Cyclin D activates the Rb tumor suppressor by mono-phosphorylation

    Anil M Narasimha et al.
    The retinoblastoma tumor suppressor regulates cell cycle progression when it's in 14 mono-phosphorylated isoforms.