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    1. Neuroscience

    Large-scale two-photon imaging revealed super-sparse population codes in the V1 superficial layer of awake monkeys

    Shiming Tang et al.
    Two-photon imaging reveals super-sparse responses to natural images in primate V1, which carry sufficient information for discrimination of the input natural images with high accuracy.
    1. Neuroscience

    Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

    Norihiro Takakuwa et al.
    The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.
    1. Neuroscience

    Representational untangling by the firing rate nonlinearity in V1 simple cells

    Merse E Gáspár et al.
    Firing rate nonlinearity recovers linear decodability of orientation information from simple cells of the primary visual cortex under uncertainty of nuisance parameters phase and spatial frequency.
    1. Developmental Biology

    Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

    Jose L Pelliccia et al.
    Genetic analyses demonstrate that Gdf3/Vg1 is a maternal effect gene required for robust Nodal signaling during different phases of embryogenesis including germ-layer formation, Kupffer's vesicle morphogenesis, and left-right patterning.
    1. Chromosomes and Gene Expression

    Rapid DNA replication origin licensing protects stem cell pluripotency

    Jacob Peter Matson et al.
    The unique cell cycle variations of pluripotent stem cells ensures that the first step in DNA replication is particularly fast and this rapid rate, in turn, restrains early differentiation.
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

    Elliot C Woods et al.
    Mucins, long associated with cancer aggression, remodel the cancer glycocalyx in a way that promotes proliferation in the metastatic site by enhancing integrin-mediated adhesion and thus driving cell cycle progression.
    1. Neuroscience

    Distinct spatiotemporal mechanisms underlie extra-classical receptive field modulation in macaque V1 microcircuits

    Christopher A Henry et al.
    The multiple component mechanisms of extra-classical receptive field modulation, with distinct dynamics, discovered in the monkey visual cortex have important implications for understanding contextual perceptual processing.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

    Lotte P Watts et al.
    The RIF1-long and short splice variants show distinct ability to protect cells from replication stress by promoting 53BP1 nuclear bodies, representing the first described functional difference between the two variants.
    1. Neuroscience

    Fine-scale computations for adaptive processing in the human brain

    Elisa Zamboni et al.
    Laminar fMRI reveals that adaptive processing involves recurrent processing within visual cortex and top-down influences from posterior parietal cortex via feedback.
    1. Structural Biology and Molecular Biophysics

    Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

    Haoqing Wang et al.
    Single particle cryoEM structure of antibody complex with HIV-1 envelope trimer reveals new mode of asymmetric recognition of trimer apex.