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    1. Neuroscience

    LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina

    Courtney A Burger et al.
    LKB1 instructs the timing and location of synapse layer emergence in the outer retina by coordinating the regulation of pre- and postsynaptic neuron maturation and transport of synapse-associated proteins.
    1. Neuroscience

    Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

    Jian Qiu et al.
    Estrogen increases hypothalamic arcuate kisspeptin neuronal excitability and glutamate release to coordinate autonomic functions for maximizing reproductive success.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diabetes regulates fructose absorption through thioredoxin-interacting protein

    James R Dotimas et al.
    Thioredoxin-Interacting Protein binds directly to fructose transporters and regulates fructose metabolism, both acutely and chronically.
    1. Neuroscience

    An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina

    Tahnbee Kim et al.
    The mouse visual system is able to detect small moving objects due to the activity of VG3-amacrine cells, an unusual type of modulatory cell that uses the transmitter glutamate to activate retinal output cells.
    1. Neuroscience

    A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila

    Aref Arzan Zarin et al.
    Generation of a premotor/motor neuron comprehensive TEM reconstruction, functional optogenetics, and recurrent network modeling reveals different phase relationships among a subset of Drosophila motor neurons in forward versus backward locomotion.
    1. Neuroscience

    Imaging neuropeptide release at synapses with a genetically engineered reporter

    Keke Ding et al.
    A series of genetically-encoded fluorescent reporters that allow imaging of neuropeptide release in vivo, with sub-second temporal and nerve terminal-level spatial resolution are developed.
    1. Developmental Biology
    2. Neuroscience

    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

    Travis A Babola et al.
    Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
    1. Cell Biology

    Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

    Kie Itoh et al.
    Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy et al.
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
    1. Cancer Biology
    2. Immunology and Inflammation

    The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

    Aaron R Lim et al.
    Diverse components of the tumor microenvironment affect T cell metabolism in ways that are crucial to improving immunotherapy.