38 results found
    1. Neuroscience

    Vision: Framing orientation selectivity

    Floris P de Lange, Matthias Ekman
    The ongoing debate on the neural basis of orientation selectivity in the primary visual cortex continues.
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    1. Computational and Systems Biology
    2. Genetics and Genomics

    A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

    David G Hendrickson et al.
    A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
    1. Neuroscience

    Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

    Efrén Álvarez-Salvado et al.
    A high-throughput behavioral paradigm and computational modeling are used to decompose olfactory navigation in walking Drosophila melanogaster into a set of quantitative relationships between sensory input and motor output.
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid et al.
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Neuroscience

    Spatial cell firing during virtual navigation of open arenas by head-restrained mice

    Guifen Chen et al.
    A mouse virtual reality system is presented which allows normal spatial behavior and place, grid and head-direction cell firing patterns in 2-D arenas, and is compatible with electrophysiology and multi-photon imaging.
    1. Neuroscience

    Emergence of social cluster by collective pairwise encounters in Drosophila

    Lifen Jiang et al.
    Cascades of transient pairwise interactions, stabilized by multisensory inputs, drive the formation of a well-organized social structure from a group of loosely distributed flies.
    1. Ecology
    2. Neuroscience

    Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase

    Sven Schenk et al.
    A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.
    1. Cancer Biology
    2. Human Biology and Medicine

    A hyperspectral method to assay the microphysiological fates of nanomaterials in histological samples

    Elliott D SoRelle et al.
    A new technique for biodistribution and targeted uptake studies of nanoparticle imaging agents is demonstrated and used to achieve levels of detail that are inaccessible through existing methods.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Domain-swapped T cell receptors improve the safety of TCR gene therapy

    Michael T Bethune et al.
    Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.

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