129 results found
    1. Neuroscience

    Experience shapes chandelier cell function and structure in the visual cortex

    Koen Seignette, Nora Jamann ... Christiaan N Levelt
    Chandelier cells in primary visual cortex show experience-dependent plasticity, respond strongly to behaviorally relevant stimuli and only weakly inhibit pyramidal cells.
    1. Neuroscience

    Stimulus vignetting and orientation selectivity in human visual cortex

    Zvi N Roth, David J Heeger, Elisha P Merriam
    Functional MRI measurements of orientation reflect coarse-scale biases that are wholly determined by second-order interactions between the stimulus aperture and the underlying orientation.
    1. Neuroscience

    Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer’s disease

    Alexa Pichet Binette, Guillaume Theaud ... PREVENT-AD Research Group
    White matter microstructure alterations in key bundles affected in Alzheimer's disease are related to amyloid and tau pathology in the preclinical phase of sporadic and autosomal-dominant Alzheimer's disease.
    1. Neuroscience

    Vision: Framing orientation selectivity

    Floris P de Lange, Matthias Ekman
    The ongoing debate on the neural basis of orientation selectivity in the primary visual cortex continues.
    Version of Record
    Insight
    1. Neuroscience

    A parameter-free statistical test for neuronal responsiveness

    Jorrit S Montijn, Koen Seignette ... J Alexander Heimel
    A simple and robust statistical test for neuronal stimulus response, that outperforms PSTH-based approaches such as t-tests and ANOVAs.
    1. Neuroscience

    Inferring illness causes recruits the animacy semantic network

    Miriam Hauptman, Marina Bedny
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

    Malgorzata Broncel, Caia Dominicus ... Moritz Treeck
    Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

    Lerato E Magosi, Yinfeng Zhang ... Marc Lipsitch
    HIV transmissions into intervention communities from control communities in the Botswana/Ya Tsie trial were similar to the reverse at baseline, and 10 times more common post-baseline, concordant with a predicted benefit of a universal test-and-treat HIV prevention intervention.
    1. Genetics and Genomics

    GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

    Nasa Sinnott-Armstrong, Sahin Naqvi ... Jonathan K Pritchard
    Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.
    1. Genetics and Genomics

    Single cell transcriptional signatures of the human placenta in term and preterm parturition

    Roger Pique-Regi, Roberto Romero ... Nardhy Gomez-Lopez
    Parturition gene regulation across multiple cell-types and placental compartments is deciphered at single cell resolution, highlighting the common role of the NFKB pathway in both term and preterm birth.

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