30 results found
    1. Neuroscience

    Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice

    Ayla Aksoy-Aksel et al.
    Dopaminergic input shapes activity of specialized amygdala inhibitory cell clusters by ionotropic and metabotropic mechanisms that may enable their selection during distinct fear-related behavioral states.
    1. Genetics and Genomics

    Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

    Swati Gaikwad et al.
    A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.
    1. Cell Biology

    Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

    Alex J B Kreutzberger et al.
    Insulin secreting cells harbor distinct subpopulations of insulin granules and loss of one or the other correlates strongly with secretory deficiencies characterizing type-1 or type-2 diabetes.
    1. Neuroscience

    Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

    Laura E Mickelsen et al.
    Single cell RNA–sequencing and neuroanatomical methods reveal unexpected molecular diversity and highly segregated spatial organization of neuronal cell types within the mouse ventral posterior hypothalamus, including the mammillary nuclei.
    1. Neuroscience

    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

    Lynne Chantranupong et al.
    Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.
    1. Chromosomes and Gene Expression

    Ribosome recycling is not critical for translational coupling in Escherichia coli

    Kazuki Saito et al.
    Without ribosome recycling factor, ribosomes in Escherichia coli accumulate in 3'-UTRs and queue upstream of stop codons, but no effects were observed on the translational coupling of neighboring genes.
    1. Neuroscience

    Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD

    Da Hee Jung et al.
    High-definition anodal transcranial stimulation alleviated cognitive deficits, affected dopaminergic neurotransmission factors, increased expression of several neurotrophic factors involving brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis.
    1. Neuroscience

    Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

    Erin A Clark et al.
    RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
    1. Neuroscience

    Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

    Elina Nagaeva et al.
    The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.

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