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    1. Cell Biology

    Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

    Manuel Alonso Y Adell et al.
    Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling

    Rajan Thakur et al.
    Phosphatidic acid regulates recycling of endocytosed plasma membrane vesicles in polarized cells through a retromer and Arf1 dependent process.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra et al.
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Cell Biology
    2. Developmental Biology

    Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

    Naonobu Fujita et al.
    Analyses of a developmentally regulated Drosophila myofiber remodeling program provide insight into induced autophagy required for T-tubule membrane reorganization, and uncover a conserved Rab2 role in autophagosome-lysosome fusion.
    1. Cell Biology

    ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins

    Lu Zhu et al.
    The lysosome membrane is a new functional location for the ESCRTs in yeast.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation

    Martin Müller et al.
    A catabolic cascade is essential to enter a stable G1/G0 quiescent state and survive extended periods of starvation.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

    Bo Li et al.
    The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

    Hongki Song et al.
    Sec17 (αSNAP) and Sec18 (NSF) are shown to act twice, to promote fusion per se and to recycle SNAREs after fusion.
    1. Structural Biology and Molecular Biophysics

    Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

    Sulochanadevi Baskaran et al.
    The first three-dimensional structure of the PI3KC3 complex I, which is involved in autophagy, provides a framework for understanding the allosteric regulation of lipid kinase activity.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

    Stefan Heinrichs et al.
    Reduced expression of MYBL2 contributes to malignancies of the blood by permitting uncontrolled expansion of blood cell progenitors, implying a tumor suppressor function for this gene.