Infants' vocalisations are contingent on their own stress physiology, and alter the inter-personal dynamics of how stress states are shared across the infant-caregiver dyad.
Single-molecule TIRF microscopy, biochemical assays and mathematical modeling demonstrate how actin-branch nucleation by the Arp2/3 complex is coordinately regulated by two biochemically distinct activators.
Analysis of suppressor mutants led to the identification of a novel signalling pathway that regulates peptidoglycan biosynthesis in Gram-positive bacteria.
To protect their food and themselves against detrimental mould fungi, the eggs of a wasp species synthesize and emit remarkable amounts of gaseous nitrogen oxides that are highly effective antimicrobials.
The synthesis capability of some amino acids is lost during the insect evolution, and hymenopteran parasitoids can make up for these deficiencies by altering free amino acid concentrations in host.
Ashley L Arthur, Amy Crawford ... Margaret A Titus
Filopodia formation requires recruitment and activation of myosin through generation of parallel, bundled actin filaments by VASP polymerase, revealing coupling between motor activation and organization of a local actin network.
Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM interaction network which gives actin assembly onset a switch-like behavior in vivo.
Lopamudra Sadhu, Nikolaos Tsopoulidis ... Oliver T Fackler
Selective involvement of Arp2/3 complex subunit isoforms ARPC5 or ARPC5L governs the distinct actin polymerization events in the nucleus or cytoplasm of CD4 T cells that are triggerd by T cell activation or DNA replication stress.
Beatriz Alvarez-Castelao, Susanne tom Dieck ... Erin M Schuman
In neurons, inhibition of the proteasome results in feedback inhibition of protein synthesis, mediated by heme-regulated kinase 1, which is optimized to act as both a sensor and an effector.