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    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Evolutionary Biology

    Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

    Anett Dunai, Réka Spohn ... Csaba Pál
    Drug-resistance declines in the laboratory in an antibiotic stress-free environment, indicating that restricting antimicrobial usage in the clinics could be a useful policy.
    1. Neuroscience

    Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish

    Chanpreet Singh, Grigorios Oikonomou, David A Prober
    Experiments in genetically modified zebrafish that are unable to produce norepinephrine show that this neurotransmitter promotes wakefulness by mediating the effects of the neuropeptide hypocretin.
    1. Physics of Living Systems

    Muscle-specific economy of force generation and efficiency of work production during human running

    Sebastian Bohm, Falk Mersmann ... Adamantios Arampatzis
    During human running, the soleus muscle was found to operate as work generator under optimal conditions for work production (high force-length potential and enthalpy efficiency) while the vastus lateralis promoted tendon energy storage and economical force generation (high force-length-velocity potential).
    1. Neuroscience

    Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

    Catia AP Silva, Annik Yalnizyan-Carson ... Christian Lohmann
    Naturally occurring activity in the developing brain regulates mitochondrial motility such that mitochondria stop at active synapses, which is probably a fundamental process in brain wiring.
    1. Physics of Living Systems

    Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis

    Rajsekhar Das, Sumit Sinha ... D Thirumalai
    Theoretical explanation and a novel mechanism are given for the observation that viscosity of embryonic non-confluent tissue shows glass-like behavior till a critical cell density and saturates at higher densities.
    1. Neuroscience

    Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements

    Ali Mashhoori, Saeedeh Hashemnia ... Aaron J Gruber
    The anterior cingulate cortex intermixes a precise spatial map with a cognitive map of the task, and spontaneously recalls multimodal information about unrealized choice outcomes during pauses in behavior after reinforcements.
    1. Neuroscience

    Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex

    Janelle MP Pakan, Scott C Lowe ... Nathalie L Rochefort
    The three main types of inhibitory neurons in mouse primary visual cortex respond differently to locomotion in darkness and during visual stimulation, revealing context-dependent responses to changes in behavioral state.
    1. Medicine

    Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron variant of concern

    Fulvia Mazzaferri, Massimo Mirandola ... Evelina Tacconelli
    Compared with casirivimab/imdevimab and bamlanivimab/etesevimab, early treatment with sotrovimab seems to reduce the time to sustained recovery among adult outpatients with mild-to-moderate SARS-CoV-2 infection due to Omicron BA.1 and BA.1.1.
    1. Neuroscience

    A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right

    Minoru Koyama, Francesca Minale ... Joseph R Fetcho
    Competition between neurons on the left and right sides of the brain drives the decision to turn left versus right in zebrafish, and potentially all vertebrates.