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    1. Computational and Systems Biology
    2. Developmental Biology

    High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

    Luciano Marcon, Xavier Diego ... Patrick Müller
    Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Biophysical clocks face a trade-off between internal and external noise resistance

    Weerapat Pittayakanchit, Zhiyue Lu ... Arvind Murugan
    Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
    1. Neuroscience

    Robo functions as an attractive cue for glial migration through SYG-1/Neph

    Zhongwei Qu, Albert Zhang, Dong Yan
    An extracellular cleavage fragment of Robo released from neurons can bind to glia-expressed SYG-1 to guide glia migration.
    1. Computational and Systems Biology
    2. Developmental Biology

    The pattern of nodal morphogen signaling is shaped by co-receptor expression

    Nathan D Lord, Adam N Carte ... Alexander F Schier
    Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.
    1. Immunology and Inflammation

    A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

    Jessica Wei, Mary J Mattapallil ... Rachel R Caspi
    LXA4 in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet, Alexandra Vandervelde ... Lendert Gelens
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Immunology and Inflammation

    Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

    Michael C Kiritsy, Katelyn McCann ... Andrew J Olive
    Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

    Vladimir A Volkov, Pim J Huis in 't Veld ... Andrea Musacchio
    Multiple NDC80 complexes in the outer kinetochore cooperate to bind the ends of depolymerizing microtubules and harness their power stroke.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Macroscopic control of cell electrophysiology through ion channel expression

    Mario García-Navarrete, Merisa Avdovic ... Krzysztof Wabnik
    A combination of mathematical modeling and live-cell imaging reveals a strategy for the rational control over cell electrophysiology though modulation of ion channel expression.
    1. Neuroscience

    Key determinants of the dual clamp/activator function of Complexin

    Mazen Makke, Alejandro Pastor-Ruiz ... Dieter Bruns
    The amphipathic helix at the C-terminus of Complexin II prevents premature secretion, whereas its N-terminal domain regulates mechanisms which are governed by the forward rate of Ca2+ binding to Synaptotagmin I.