RNA binding is a key input of an active chromatin complex and maintenance of stem cell fate.

PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.

Differences in promoter affinity and MYC levels explain distinct expression profiles induced by physiological and oncogenic MYC.

Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.

Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.

The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.

Sea3, a presumed subunit of the GATOR2 complex in fission yeast, is required for the GATOR1 function that attenuates TORC1 in parallel with the TSC complex and Gcn2 kinase.

Rhythmic centrifugal waves of auxin traveling through the tissue provides high definition positional information to cells that is not only spatial but also temporal.

Variable petal number in Cardamine hirsuta is explained by regulatory changes in the MADS-box gene APETALA1 that relaxed its epistasis over mapped QTL in the C. hirsuta genome.

A high-throughput functional validation system for large numbers of candidate disease genes enables in vivo functional testing of specific gene variants.