2,480 results found
    1. Physics of Living Systems

    Phenotyping single-cell motility in microfluidic confinement

    Samuel A Bentley, Hannah Laeverenz-Schlogelhofer ... Kirsty Y Wan
    A droplet microfluidics approach to stably trap and phenotype individual micron-sized algae reveals their distinct but stereotyped movement patterns and how they respond in real time to local environmental cues, including novel boundary circling behaviour under strong confinement.
    1. Epidemiology and Global Health

    COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron)

    Wan Yang, Jeffrey L Shaman
    Model-inference reconstructed SARS-CoV-2 transmission dynamics in South Africa during March 2020 to February 2022, and quantified the immune erosion potential and transmissibility of three major variants (Beta, Delta, and Omicron), highlighting their common characteristics and the need for more proactive preparedness.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang, Supansa Pantoom, Yao-Wen Wu
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

    Jianwen Chen, Bao Zhao ... Haitao Wen
    Deficiency or pharmacological inhibition of O-glcNac transferase (OGT) enhances tumor immunity in colorectal cancer models.
    1. Stem Cells and Regenerative Medicine

    In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

    Bingqiang Wen, Guolun Wang ... Vladimir V Kalinichenko
    Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory responses of Drosophila are encoded in the organization of projection neurons

    Kiri Choi, Won Kyu Kim, Changbong Hyeon
    The organization of olfactory projection neurons and their synaptic connectivity with third-order neurons studied along with olfactory responses suggest that the labeled-line design is partially at work in the Drosophila olfactory system.
    1. Ecology

    Increasing plant diversity with border crops reduces insecticide use and increases crop yield in urban agriculture

    Nian-Feng Wan, You-Ming Cai ... Bo Li
    Plant diversification can make an important contribution to ecological intensification and the sustainable use of associated ecosystem services in an urban ecosystem.
    1. Neuroscience

    Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources

    Hua Wen, Jeffrey M Hubbard ... Paul Brehm
    The delayed-onset of asynchronous transmitter release seen in neurons that fire repeatedly is triggered by a different source of calcium from that which triggers synchronous transmitter release.
    1. Computational and Systems Biology
    2. Neuroscience

    3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images

    Chentao Wen, Takuya Miura ... Koutarou D Kimura
    A deep learning-based pipeline was developed for extracting cellular signals flexibly from moving cells in 3D time lapse images, and it outperformed previous methods under different imaging conditions.
    1. Neuroscience

    Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

    Guoqiang Wan, Maria E Gómez-Casati ... Gabriel Corfas
    Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.

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