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    1. Cell Biology

    Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

    Ian F Price, Hannah L Hertz ... Wen Tang
    A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

    William Wan, Mairi Clarke ... John AG Briggs
    Cryo-electron tomography reveals the structure and arrangement of the VP40 matrix protein lattice that mediates the formation of Ebola and Marburg virus particles.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    Tao Zhang, Liyang Wan ... Hongbin Lu
    Single-cell RNA sequencing to delineate the comprehensive postnatal RC enthesis growth from as early as postnatal day 1 to postnatal day 56.
    1. Neuroscience

    Single-cell RNAseq analysis of spinal locomotor circuitry in larval zebrafish

    Jimmy J Kelly, Hua Wen, Paul Brehm
    Single-cell transcriptomics of larval zebrafish spinal cord reveal ion channels and exocytotic machinery that enhance transmitter release in neuronal types shown to mediate high-speed swimming and escape behavior.
    1. Cancer Biology

    Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone

    Wing Yin Cheng, HoangDinh Huynh ... Yihong Wan
    The PPARγ protein acts in macrophages to inhibit breast cancer progression and mediate the anti-tumor effects of rosiglitazone by suppressing Gpr132 – a pro-tumor and pro-inflammatory factor in macrophages.
    1. Cell Biology

    Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation

    Xiaoxiao Li, Wei Wei ... Yihong Wan
    Orphan nuclear receptor Nur77 protects bone by enabling a timely termination of osteoclast differentiation.
    1. Developmental Biology
    2. Neuroscience

    linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells

    Valerie A Tornini, Liyun Miao ... Antonio J Giraldez
    Two putative long noncoding RNAs in zebrafish encode micropeptides with homology to the vertebrate-specific chromatin architectural protein, Hmgn1, which are required for development of vertebrate-specific brain cell types.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan, Yijing Su ... Shuli Xia
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
    1. Ecology

    Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

    Chao Wen, Yuyi Lu ... Lars Chittka
    Behavioral studies reveal that bumblebees distinguish between continuous and interrupted strings by using a combination of image matching and associative learning.
    1. Cancer Biology
    2. Cell Biology

    Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

    Kai Fu, Xin Sun ... Fengyi Wan
    Building on previous work (Fu et al., 2016), we demonstrate the critical role of Sam68 in orchestrating genotoxic stress-initiated NF-κB signaling in the colon and the pathophysiological relevance of Sam68-dependent NF-κB activation in colonic cell survival/recovery from extrinsic DNA damage.