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    1. Neuroscience

    Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease

    Peter M Lauro, Shane Lee ... Wael F Asaad
    Motor signs of Parkinson’s disease such as tremor and bradykinesia are independently expressed and exhibit distinct signatures of neural activity that can independently decoded from subthalamic and cortical recordings using interpretable machine learning.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation

    Nikola Ojkic, Javier López-Garrido ... Robert G Endres
    Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.
    1. Cell Biology
    2. Computational and Systems Biology

    Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

    Takahiro Takano, Amanda M Wahl ... David I Yule
    Measurement of physiological intracellular Ca2+ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    General principles for the formation and proliferation of a wall-free (L-form) state in bacteria

    Romain Mercier, Yoshikazu Kawai, Jeff Errington
    A wide range of bacterial species can switch into a cell wall-free state that does not require the FtsZ-based division machinery to proliferate.
    1. Chromosomes and Gene Expression

    Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes

    Oliver Crawley, Consuelo Barroso ... Enrique Martinez-Perez
    By specifically antagonizing binding of complexes carrying COH-3/4 kleisins, WAPL-1 regulates chromosome structure and cohesion throughout meiotic prophase.
    1. Cancer Biology
    2. Physics of Living Systems

    Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

    Debanjan Goswami, De Chen ... Thomas Turbyville
    Compared to other isoforms of RAS, KRAS4b has unique membrane diffusion behavior related to its biology, and the two major domains of the protein both contribute to this diffusion behavior.
    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain, Carl N Wivagg ... Ethan C Garner
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Plant Biology

    Cell-type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis

    Alicia Kairouani, Dominique Pontier ... Thierry Lagrange
    Musashi-mediated post-transcriptional mechanisms regulate glucuronoxylan modification and secondary cell wall formation in the supportive fibre cells of stem in plants.
    1. Developmental Biology

    Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

    Andrew Liu, Jessica O’Connell ... Richard W Carthew
    Two atypical cadherins regulate organ growth by tuning the coupling of cell cycle duration to organ size.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A cell wall synthase accelerates plasma membrane partitioning in mycobacteria

    Takehiro Kado, Zarina Akbary ... M Sloan Siegrist
    A newly established reversible model of membrane departitioning and repartitioning in bacteria uncovers the role of a cell wall synthase in regulating membrane partitioning.