307 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

    Ting Su et al.
    The structure of the VemP-stalled ribosome reveals a helix-double turn-helix conformation of the nascent chain within the ribosomal tunnel, illustrating how secondary structure formation directly at the peptidyltransferase center of the ribosome can induce translational arrest.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation

    Sylvain Durand et al.
    Small regulatory RNAs are able to modulate mRNA degradation rates by controlling access to the 5' end of mRNAs in bacteria.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov et al.
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Neuroscience

    The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion

    Peter Soba et al.
    A cell surface receptor called Ret enables neurons to establish and maintain the organized arrays of dendrites that support communication between neurons.
    1. Cell Biology

    GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

    Hung-Hsiang Huang et al.
    GnT1IP-L is a membrane bound glycoprotein that interacts with MGAT1 in the Golgi, but not in the endoplasmic reticulum, to regulate complex N-glycan synthesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

    Viktoria Désirée Paul et al.
    Two newly identified assembly factors for the ribosome-associated iron-sulfur protein Rli1 reveal a general mechanism for how the cytosolic iron-sulfur protein assembly (CIA) machinery recruits apoproteins.
    1. Ecology
    2. Epidemiology and Global Health

    Effectiveness of traveller screening for emerging pathogens is shaped by epidemiology and natural history of infection

    Katelyn M Gostic et al.
    Pathogen natural history, epidemiological knowledge, human behavior and epidemic progression determine whether symptom screening and questionnaires are effective barriers to geographic spread of infection by travelers.
    1. Neuroscience

    A causal role for right temporo-parietal junction in signaling moral conflict

    Ignacio Obeso et al.
    Disrupting the right temporo-parietal junction did not change the general motivation to give or adapt behavior to social reputation cues, but specifically reduced the impact of moral-material conflict.
    1. Neuroscience

    Human VMPFC encodes early signatures of confidence in perceptual decisions

    Sabina Gherman, Marios G. Philiastides
    Simultaneous EEG-fMRI reveals neural representations of decision confidence unfolding prior to explicit perceptual choices, in a region of the ventromedial prefrontal cortex typically linked to reward processing and value-based decisions.

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