Orthologous proteins display different mutational robustness that can be leveraged to improve prediction of functional sequences.

A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.

Current models of Alzheimer's disease that put mitochondria as an endpoint of disease should be reconsidered because genetic defects affecting mitochondria by themselves can also regulate Alzheimer’s disease risk factor apolipoprotein E (APOE) expression and secretion.

LUZP1 is required for proper cilia and cytoskeleton formation.

Drep-2 is the first representative of the evolutionary conserved CIDE-N protein family found at synapses and is required for associative learning by functionally intersecting with metabotropic signaling.

The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.

Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.

An ecological trade-off between growth and death enables microbes with different dispersal strategies to coexist on particulate matter in the oceans.

A microfluidic experimental approach combined with dynamical systems theory reveals how to entrain an embryonic oscillator, the segmentation clock, and allows for the quantification of its entrainment properties.

Analysis of mutant cells combined with biochemical experiments reveals that CEP78 is recruited to the centrosome by CEP350 and regulates ciliogenesis and ciliary length control through CP110-dependent and CP110-independent mechanisms, respectively.