1,155 results found
    1. Structural Biology and Molecular Biophysics

    Sequential conformational rearrangements in flavivirus membrane fusion

    Luke H Chao et al.
    The West Nile Virus envelope protein catalyzes membrane fusion through low-pH induced conformational rearrangement, with a rate determined by the formation of two trimeric complexes at the contact zone between the virus and target membrane.
    1. Ecology
    2. Epidemiology and Global Health

    Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C

    Marta S Shocket et al.
    Mechanistic, trait-based models for transmission of West Nile virus and observed incidence of human West Nile disease cases in the US both show optimal transmission at 24-25°C.
    1. Immunology and Inflammation

    AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

    Edward T Schmid et al.
    AXL enables the priming of the antiviral adaptive immune response by limiting the production of type I interferons in dendritic cells.
    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Ecology
    2. Evolutionary Biology
    House sparrow illustration

    The Natural History of Model Organisms: The house sparrow in the service of basic and applied biology

    Haley E Hanson et al.
    The house sparrow, one of the most ubiquitous birds in the world, is now used extensively in studies across disciplines in the life sciences.
    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Neuroscience

    Inhibition stabilization is a widespread property of cortical networks

    Alessandro Sanzeni et al.
    The strongly coupled theoretical regime describes the function of mouse sensory and motor cortical areas.
    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson et al.
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.

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