4,196 results found
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Neuroscience

    Neuroscience: How to train a neuron

    Rui P Costa, Alanna J Watt, P Jesper Sjöström
    Version of Record
    Insight
    1. Neuroscience

    Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

    Wei Deng, Mark Mayford, Fred H Gage
    By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

    Xiao-Wei Chen, He Wang ... David Ginsburg
    COPII vesicles regulate the metabolism of cholesterol through the selective transport of secretory proteins.
    1. Neuroscience

    Decoding the neural mechanisms of human tool use

    Jason P Gallivan, D Adam McLean ... Jody C Culham
    Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others represent these two types of action separately.
    1. Neuroscience

    A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by Gαs signaling

    Stanislav Nagy, Charles Wright ... David Biron
    C. elegans exhibits two distinct behavioural macro-states, active and quiet wakefulness, and protein kinase A regulates switching between these two states.
    1. Neuroscience

    Skill learning strengthens cortical representations of motor sequences

    Tobias Wiestler, Jörn Diedrichsen
    Detailed analysis of fMRI data shows that sequences of movements are associated with individual patterns of neural activity that become more distinct with training.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

    Mari Nishino, Jonathan W Choy ... Jack Taunton
    Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder.
    1. Cell Biology

    An essential and NSF independent role for α-SNAP in store-operated calcium entry

    Yong Miao, Cathrine Miner ... Monika Vig
    α-SNAP mediated rearrangement of Stim1 and Orai1 molecules within CRAC channel clusters is required for store-operated calcium entry.
    1. Neuroscience

    Segregation of complex acoustic scenes based on temporal coherence

    Sundeep Teki, Maria Chait ... Timothy D Griffiths
    Experiments with realistic acoustic stimuli have revealed that humans distinguish salient sounds from background noise by integrating frequency and temporal information.

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