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    1. Ecology
    2. Evolutionary Biology

    Comparative genomics explains the evolutionary success of reef-forming corals

    Debashish Bhattacharya, Shobhit Agrawal ... Paul G Falkowski
    The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.
    1. Neuroscience

    Shifting from fear to safety through deconditioning-update

    Bruno Popik, Felippe Espinelli Amorim ... Lucas De Oliveira Alvares
    Deconditioning is a safe and efficient new approach to updating traumatic memories, in which fear memory is rewritten to a very low level in a long-lasting way.
    1. Cell Biology

    Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

    Lydia WT Cheung, Katarzyna W Walkiewicz ... Gordon B Mills
    The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.
    1. Biochemistry and Chemical Biology

    Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

    Laurie Peverini, Sophie Shi ... Pierre-Jean Corringer
    Conformational motions elicited by antagonists, partial agonists, and agonists in serotonin-gated ion channels 5-HT3AR progressively spread from the extracellular to the transmembrane domain.
    1. Microbiology and Infectious Disease

    Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

    Jean-Emmanuel Hugonnet, Dominique Mengin-Lecreulx ... Michel Arthur
    Production of the L,D-transpeptidase YcbB and elevated synthesis of the (p)ppGpp alarmone reveals a new mode of peptidoglycan polymerization that bypasses the D,D-transpeptidase activity of PBPs and leads to broad-spectrum β-lactam resistance in Escherichia coli.
    1. Physics of Living Systems

    Ciliary chemosensitivity is enhanced by cilium geometry and motility

    David Hickey, Andrej Vilfan, Ramin Golestanian
    Chemical receptors located on cilia can achieve particle capture rates that are many times higher than receptors located on a flat epithelial surface.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Reconstitution reveals two paths of force transmission through the kinetochore

    Grace E Hamilton, Luke A Helgeson ... Trisha N Davis
    Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.
    1. Genetics and Genomics
    2. Neuroscience

    The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

    Shahar Alon, Sandra C Garrett ... Eli Eisenberg
    The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
    1. Medicine

    The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

    Karla J Suchacki, Benjamin J Thomas ... William P Cawthorn
    The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria, Thiago S Nakahara ... Darren W Logan
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.