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    1. Neuroscience
    2. Physics of Living Systems

    Revealing architectural order with quantitative label-free imaging and deep learning

    Syuan-Ming Guo, Li-Hao Yeh ... Shalin B Mehta
    Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.
    1. Computational and Systems Biology
    2. Neuroscience

    A generalizable brain extraction net (BEN) for multimodal MRI data from rodents, nonhuman primates, and humans

    Ziqi Yu, Xiaoyang Han ... Jianfeng Feng
    The Brain Extraction Network (BEN) provides a robust, accurate, and generalizable solution not only for extracting brain tissue from multimodal MRI data in rodents, non-human primates, and humans, but also for improving the accuracy of downstream neuroimaging processing tasks.
    1. Neuroscience

    Individual behavioral trajectories shape whole-brain connectivity in mice

    Jadna Bogado Lopes, Anna N Senko ... Gerd Kempermann
    When genes and environment are controlled, mice still develop stable differences in behavior, which are associated with large-scale differences in brain structure and connectivity.
    1. Neuroscience

    Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

    Ana MG Manea, Anna Zilverstand ... Jan Zimmermann
    Neuroimaging proves to be a powerful tool for capturing spatial and temporal dynamics across the whole nonhuman primate brain, bridging the gap between human and animal models.
    1. Neuroscience

    In situ X-ray-assisted electron microscopy staining for large biological samples

    Sebastian Ströh, Eric W Hammerschmith ... Adrian Andreas Wanner
    In situ X-ray imaging of biological tissue samples in staining solution while they are being processed for electron microscopy reveals novel insights into the diffusion-reaction kinetics, tissue mechanics, and staining quality.
    1. Neuroscience

    Cognitive regulation alters social and dietary choice by changing attribute representations in domain-general and domain-specific brain circuits

    Anita Tusche, Cendri A Hutcherson
    Regulatory success operates by goal-consistent increases and decreases of distinct attribute representations in generic neural hubs and in domain-specific brain regions, explaining when and why regulatory success generalizes across domains and contexts.
    1. Evolutionary Biology
    2. Neuroscience

    Neural defensive circuits underlie helping under threat in humans

    Joana B Vieira, Andreas Olsson
    The activation of defence brain circuits drives decisions to help conspecifics under threat.
    1. Neuroscience

    A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

    Ariane C Boehm, Anja B Friedrich ... Ilona C Grunwald Kadow
    Behavioral and in vivo imaging analysis in the fly suggests that mating-related sensory experience regulates female odor perception and expression of choice behavior through a dopamine-gated learning circuit.
    1. Neuroscience

    Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei

    Zhengchao Xu, Zhao Feng ... Anan Li
    Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.
    1. Neuroscience

    Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret

    Célian Bimbard, Charlie Demene ... Yves Boubenec
    Functional UltraSound imaging allows mapping tonotopic organisation in multiple auditory subcortical and cortical brain structures with an unprecedented spatial functional resolution, while giving access to long-distance top-down connectivity pattern from frontal cortex to auditory cortex.