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Computational and Systems Biology
Mitochondrial DNA copy number variation across human cancers
Ed Reznik et al.
Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.
Structural Biology and Molecular Biophysics
Immunology and Inflammation
Structural basis for the prion-like MAVS filaments in antiviral innate immunity
Hui Xu et al.
Mitochondrial anti-viral signaling proteins form three-stranded helical filaments in launching innate immune responses against RNA viruses.
Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron
Nils O Lindström et al.
The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
Brad Evans et al.
Stem Cells and Regenerative Medicine
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish
Matthew Gemberling et al.
Neuregulin1 is induced upon cardiac injury in adult zebrafish, and is sufficient to drive massive proliferative growth of the heart.
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in
Magda L Atilano et al.
Modulation of insulin signalling could be an effective therapeutic approach against hexanucleotide repeat expansion related to c9ALS/FTD neurodegenerative diseases.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
King Faisal Yambire et al.
Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
Chromosomes and Gene Expression
mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs
Qiuying Liu et al.
Repressing the conserved pro-differentiation let-7 microRNAs through limiting Ago2 levels is critical to maintaining pluripotency in stem cells.
Biochemistry and Chemical Biology
Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin
Melissa V Gammons et al.
An unusual molecular mechanism has been revealed based on ultrastable histidine cluster co-aggregation underlying feedback control of an ancient cell communication pathway.
Genetics and Genomics
Recurrent evolution of high virulence in isolated populations of a DNA virus
Tom Hill, Robert L Unckless
The same host–virus interactions can evolve multiple times in nature, due to the high effective mutation rate of viruses, and provide interesting systems of study.
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