318 results found
    1. Neuroscience

    Regulation of food intake by mechanosensory ion channels in enteric neurons

    William H Olds, Tian Xu
    Manipulating the activity of ‘stretch-sensitive’ ion channels in neurons innervating the digestive system of fruit flies has dramatic effects on food intake, suggesting that these ion channels could be targets for drugs to help tackle obesity.
    1. Cell Biology
    2. Developmental Biology

    Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos

    Matthew Richard Johnson et al.
    In early Drosophila embryos, histone H2Av continuously exchanges between cytoplasmic lipid droplets, a process that modulates H2Av import into nuclei and constitutes a novel post-translational strategy to regulate nuclear H2Av levels.
    1. Neuroscience

    Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds

    Minhui Ouyang et al.
    Diffusion-MRI-based cerebral cortical microstructure encoding regionally differential dendritic arborization and synaptic formation at birth robustly predicts future 2-year-old cognitive and language outcomes with regionally heterogeneous contribution that exhibits functional selectivity.
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen et al.
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

    David Barneda et al.
    An interaction between the brown fat protein CIDEA and the phospholipid phosphatidic acid is vital for the expansion of intracellular lipid droplets for energy storage.
    1. Cell Biology

    Seipin is required for converting nascent to mature lipid droplets

    Huajin Wang et al.
    Seipin oligomers dynamically interact with small, nascent lipid droplets near the endoplasmic reticulum to convert them into larger, mature lipid droplets in a newly identified step of lipid droplet formation.
    1. Chromosomes and Gene Expression

    High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

    Douglas Maya Miles et al.
    Ploidy is stably maintained in Saccharomyces cerevisae by a tight coordination between histone levels and cell cycle events.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets

    Valeria Zoni et al.
    In parallel to protein-driven processes, characteristic physicochemical properties of the endoplasmic reticulum membrane modulate intracellular fat accumulation and lipid droplet formation.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

    Xiaodong Zhang et al.
    The survival and growth of solid tumor cells in hypoxia is dependent on fatty acid storage in triglyceride lipid droplets promoted by HIG2.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

    Florian Wilfling et al.
    The targeting of proteins from the endoplasmic reticulum to lipid droplets relies on surface modulation of the lipid droplet by the Arf1/COPI machinery.

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