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    1. Stem Cells and Regenerative Medicine

    Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche

    Su Wang et al.
    Wnt signaling regulates cellular redox in the germline stem cell differentiation niche via a novel regulatory mechanism, thereby controlling germ line stem cell progeny differentiation.
    1. Stem Cells and Regenerative Medicine

    Embryonic attenuated Wnt/β-catenin signaling defines niche location and long-term stem cell fate in hair follicle

    Zijian Xu et al.
    Long-term hair follicle stem cells arise by embryonic progenitor cells occupying a niche location that is defined by attenuated Wnt/β-catenin signal.
    1. Cell Biology
    2. Developmental Biology

    The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

    Ling-Shih Chang et al.
    Two cancer related proteins, tyrosine phosphatase PTPRK and ubiquitin ligase ZNRF3, interact to downregulate Wnt receptors, thereby regulating Spemann organizer function during Xenopus development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

    David Melamed, Daniel Kalderon
    Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
    1. Cell Biology

    A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

    Mira I Pronobis et al.
    A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9

    Laurens M van Tienen et al.
    BCL9/Legless is an integral component of the Wnt enhanceosome, harboring binding sites in its conserved C-terminus for multiple core components of this complex including ChiLS and Groucho/TLE.
    1. Developmental Biology

    Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration

    Shashank Gandhi et al.
    Chromatin remodeler Hmga1 has two separable functions in neural crest development, first neural crest specification at the neural plate border and later in Wnt-dependent emigration from the neural tube.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

    Ho-Jin Lee et al.
    The ligand-binding pocket of the Dishevelled PDZ domain can be occupied by Dishevelled's own highly conserved C-terminus, inducing a closed conformation that is ‘opened’ when Wnt signaling stimulates interaction between Frizzled and Dishevelled.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

    Emiko Mihara et al.
    Lipidated and highly hydrophobic Wnt ligands form a complex with the serum glycoprotein afamin, and can be purified and stored in a biologically active form without detergents.
    1. Developmental Biology
    2. Cell Biology

    Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

    Ariel M Pani, Bob Goldstein
    Free, extracellular dispersal of Wnt proteins generates a long-range gradient during animal development and is required for signaling.