167 results found
    1. Neuroscience

    Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

    Yingying Chen, Jeong Han Lee ... Ebenezer N Yamoah
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi, Ralph Patrick ... Richard P Harvey
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Developmental Biology

    scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

    Alexandre P Thiery, Ailin Leticia Buzzi ... Andrea Streit
    Neural plate border cells co-express neural, neural crest, and placodal transcriptional programs before cell fate decisions occur and are transcriptionally heterogeneous along the antero-posterior and medial-lateral axis.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung, Daniel Wells ... Donald F Conrad
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Computational and Systems Biology

    DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

    Vivian Tam, Peikai Chen ... Danny Chan
    Deep and comprehensive proteomic resource of human intervertebral disc at high spatial resolution with a methodological flow reveals new insights in disc homeostasis and degeneration.
    1. Neuroscience

    Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations

    Stephen M Smith, Lloyd T Elliott ... Karla L Miller
    Imaging of structure and function in the brain from thousands of participants was used along with genetics and biophysical measures to study many different aspects of how the brain ages.
    1. Cell Biology
    2. Developmental Biology

    Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

    Leah C Biggs, Otto JM Mäkelä ... Marja L Mikkola
    The hair follicle dermal condensate is populated via migration, and the cells exhibit early changes in cell shape and cell cycle status; Fgf20 primes these cellular and molecular events.
    1. Cancer Biology
    2. Cell Biology

    MELK is not necessary for the proliferation of basal-like breast cancer cells

    Hai-Tsang Huang, Hyuk-Soo Seo ... Nathanael S Gray
    The inhibitory or deletion effect of MELK does not impair the proliferation of basal-like breast cancer cell lines.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth, Kristin L Muench ... Theo D Palmer
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Stem Cells and Regenerative Medicine

    Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

    Jacob W Klemm, Chloe Van Hazel, Robin E Harris
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid

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