1,225 results found
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

    Emiko Mihara, Hidenori Hirai ... Junichi Takagi
    Lipidated and highly hydrophobic Wnt ligands form a complex with the serum glycoprotein afamin, and can be purified and stored in a biologically active form without detergents.
    1. Developmental Biology
    2. Cell Biology

    Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

    Benjamin Mattes, Yonglong Dang ... Steffen Scholpp
    Wnt signaling regulates its effective signaling range by controlling Wnt ligand transport on signaling filopodia within vertebrate tissues.
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen, Lei Li ... Lin Mei
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Cell Biology
    2. Developmental Biology

    Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

    Amrutha Kizhedathu, Rose Sebastian Kunnappallil ... Arjun Guha
    Wnts can act synergistically to affect G2 arrest via transcriptional upregulation of a Checkpoint Kinase in the absence of any detectable DNA damage.
    1. Stem Cells and Regenerative Medicine

    Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

    John P Russell, Xinhong Lim ... Cynthia L Andoniadou
    Stem cells of the pituitary gland contribute to organ growth cell non-autonomously by promoting proliferation of committed progenitors through WNT ligand secretion.
    1. Stem Cells and Regenerative Medicine

    Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration

    Rachel Lander, Christian P Petersen
    Signaling molecules expressed in overlapping body-wide transcriptional gradients determine central axis positional identity in whole-body regeneration.
    1. Developmental Biology
    2. Neuroscience

    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

    Benjamin D Gastfriend, Hideaki Nishihara ... Eric V Shusta
    Activation of Wnt/β-catenin signaling in endothelial progenitors derived from human pluripotent stem cells partially induces the specialized blood–brain barrier phenotype while the same treatment in matured endothelial cells is less efficacious.
    1. Developmental Biology
    2. Evolutionary Biology

    Ectodermal Wnt signaling, cell fate determination, and polarity of the skate gill arch skeleton

    Jenaid M Rees, Victoria A Sleight ... J Andrew Gillis
    Spatially distinct ectodermal Wnt and endodermal Shh signals serve to polarize the skate gill skeleton.
    1. Developmental Biology

    Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

    M Lucila Scimone, Lauren E Cote ... Peter W Reddien
    Single-cell RNA sequencing identifies an adult regional gene expression map in planarian muscle that includes two FGFRL-Wnt circuits controlling head and trunk tissue pattern.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

    Ruihua Ma, Angelica S Martínez-Ramírez ... Beatriz Sosa-Pineda
    Mouse genetic approaches show that multiple Wnt endothelial sources orchestrate the spatiotemporal distribution of hepatocyte functions during liver maturation and respecify metabolic zonation during liver repair.

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