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    1. Neuroscience

    Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

    Tim James Viney, Minas Salib ... Peter Somogyi
    GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
    1. Neuroscience

    The songbird lateral habenula projects to dopaminergic midbrain and is important for normal vocal development

    Andrea Roeser, Han Kheng Teoh ... Jesse Goldberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Exceptional
    • Incomplete
    1. Developmental Biology

    Neuroprotective role of Hippo signaling by microtubule stability control in C. elegans

    Hanee Lee, Junsu Kang ... Junho Lee
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Cell type-specific contributions to a persistent aggressive internal state in female Drosophila

    Hui Chiu, Alice A. Robie ... Catherine E. Schretter
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Exploiting functional regions in the viral RNA genome as druggable entities

    Dehua Luo, Yingge Zheng ... Dengguo Wei
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in Drosophila

    Yifu Han, Chun Chien ... Dion Dickman
    A new tool enables electrophysiological isolation of input-specific neurotransmission in a powerful model glutamatergic circuit.
    1. Microbiology and Infectious Disease

    Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis

    Xingye Wang, Jie Wang ... Beinan Wang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Balance of activity during a critical period tunes a developing network

    Iain Hunter, Bramwell Coulson ... Richard A Baines
    Neurodevelopmental critical periods act to integrate activity to encode homeostatic set points that remain fixed thereafter.
    1. Developmental Biology

    Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

    Timothy J Mead, Daniel R Martin ... Suneel S Apte
    Proteolytic cleavage of the extracellular matrix glycoprotein fibrillin-2 by the secreted metalloprotease ADAMTS6 influences skeletal development by modulating fibrillin microfibril abundance and GDF5/BMP signaling, illustrating the crucial role of extracellular matrix proteostatic mechanisms in growth factor regulation during morphogenesis.
    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

    Audrey M Hendley, Arjun A Rao ... Matthias Hebrok
    Single-cell RNA-sequencing analyses and functional studies define heterogeneity within the pancreatic ductal tree and unique properties of subpopulations of duct cells including an epithelial-mesenchymal transcriptomic axis and roles in chronic pancreatic inflammation.
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