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    1. Neuroscience

    Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

    B Semihcan Sermet, Pavel Truschow ... Carl CH Petersen
    Two distinct thalamocortical pathways were found to provide differential excitatory synaptic input to distinct cell-types across layers of mouse primary somatosensory barrel cortex.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition

    Alba Pacheco-Moreno, Francesca L Stefanato ... Andrew W Truman
    Genomics and genetics were used to identify specialized metabolites employed by Pseudomonas bacteria to suppress the growth of potato pathogens, which revealed a key role for cyclic lipopeptides.
    1. Developmental Biology

    Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

    Siyuan Cheng, Ivan Fan Xia ... Stefania Nicoli
    Flow hemodynamic activation of endothelial klf2a is a mechanism regulating initial vascular smooth muscle cell differentiation on circle of Willis arteries.
    1. Neuroscience

    First spikes in visual cortex enable perceptual discrimination

    Arbora Resulaj, Sarah Ruediger ... Massimo Scanziani
    A brief time window of visually evoked activity in mouse primary visual cortex is sufficient for perceptual discrimination.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Recreating the synthesis of starch granules in yeast

    Barbara Pfister, Antoni Sánchez-Ferrer ... Samuel C Zeeman
    Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

    Claudio A Franco, Martin L Jones ... Holger Gerhardt
    A threshold level of blood flow initiates developmental blood vessel regression; this threshold can be regulated by non-canonical Wnt ligands.
    1. Ecology

    Tritrophic metabolism of plant chemical defenses and its effects on herbivore and predator performance

    Ruo Sun, Xingcong Jiang ... Daniel Giddings Vassão
    Genetic manipulation demonstrates the costs and benefits of detoxifying glucosinolate plant defenses in a pest insect and its predator.
    1. Cancer Biology

    ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

    Wentong Fang, Chengheng Liao ... Qing Zhang
    ZHX2 controls HIF1α oncogenic signaling and tumorigenesis in triple-negative breast cancer.
    1. Biochemistry and Chemical Biology

    Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

    Makenna M Morck, Debanjan Bhowmik ... Kathleen M Ruppel
    Hypertrophic cardiomyopathy-causing mutations in the light chain-binding region of β-cardiac myosin's lever arm appear to disrupt myosin tail-based autoinhibition, while mutations in the pliant region of the lever arm reduce autoinhibition in the presence of actin and impact myosin’s powerstroke.