2,182 results found
    1. Chromosomes and Gene Expression

    Condensin controls recruitment of RNA polymerase II to achieve nematode X-chromosome dosage compensation

    William S Kruesi et al.
    C. elegans equalizes the expression of X-chromosome genes between the sexes by reducing the recruitment of RNA polymerase II to promoters of X-linked genes in hermaphrodites, using a chromosome-restructuring complex called condensin.
    1. Chromosomes and Gene Expression

    Chromosome-wide mechanisms to decouple gene expression from gene dose during sex-chromosome evolution

    Bayly S Wheeler et al.
    A chromosome-wide mechanism balances X-linked gene expression between the sexes in C. elegans, but no similar chromosome-wide mechanism balances gene expression between X chromosomes and autosomes.
    1. Chromosomes and Gene Expression

    Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

    Ava C Carter et al.
    A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
    1. Chromosomes and Gene Expression

    Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation

    Sarah Elizabeth Albritton et al.
    Gene regulatory elements can target a chromatin regulatory complex to a single chromosome in the genome through hierarchical specification and long distance cooperation.
    1. Chromosomes and Gene Expression

    Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

    Behnom Farboud et al.
    RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and determine nematode sex by controlling alternative non-productive pre-mRNA splicing of the master sex-determination switch gene.
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris et al.
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Developmental Biology

    Guy1, a Y-linked embryonic signal, regulates dosage compensation in Anopheles stephensi by increasing X gene expression

    Yumin Qi et al.
    For the first time in a mosquito species an initial Y chromosome signal has been shown to regulate dosage compensation by increasing X chromosome gene expression.
    1. Evolutionary Biology

    Free-living human cells reconfigure their chromosomes in the evolution back to uni-cellularity

    Jin Xu et al.
    Human cell lines regress to become ‘de-sexualized’ by reconfiguring to a 2:3 X/A ratio of high fitness, thus shedding light on the evolution of mammalian sex chromosomes.
    1. Developmental Biology

    Regulation of X-linked gene expression during early mouse development by Rlim

    Feng Wang et al.
    Single embryo RNA-seq combined with mouse genetics provides a comprehensive view on the roles of Rlim and Xist for the regulation of X-linked gene expression during early mouse embryogenesis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

    Daniel Andergassen et al.
    The X-linked loci Firre and Dxz4 are involved in autosomal gene regulation rather than XCI biology.

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