1,537 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

    Robert J Tetley, Guy B Blanchard ... Bénédicte Sanson
    Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    J Stephan Wichers, Gerry Tonkin-Hill ... Anna Bachmann
    Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.
    1. Cell Biology
    2. Developmental Biology

    Human embryo polarization requires PLC signaling to mediate trophectoderm specification

    Meng Zhu, Marta Shahbazi ... Magdalena Zernicka Goetz
    Functional analyses of in vitro fertilized, preimplanation human embryos reveal that the first lineage segregation depends on cell polarization signaling that is regulated by Phospholipase C (PLC) activity.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

    Hansen Wang, Lisa D Muiznieks ... Gerold Schmitt-Ulms
    The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.
    1. Microbiology and Infectious Disease

    An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics

    Prahathees J Eswara, Robert S Brzozowski ... Kumaran S Ramamurthi
    GpsB in Staphylococcus aureus directly regulates the central cell division protein FtsZ, a different function from that assigned for GpsB in other closely related organisms.
    1. Developmental Biology
    2. Neuroscience

    Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells

    Tanya L Brown, Emma C Horton ... Jeffrey P Rasmussen
    Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.
    1. Genetics and Genomics

    Rapid and precise genome engineering in a naturally short-lived vertebrate

    Claire N Bedbrook, Ravi D Nath ... Anne Brunet
    Rapid and efficient CRISPR/Cas9-mediated knock-in of fluorescent reporters at various genomic loci enables cell- and tissue-specific expression and establishes the short-lived African killifish as a vertebrate system for precise genetic engineering at scale.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

    Mark F Sabbagh, Jacob S Heng ... Jeremy Nathans
    Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.
    1. Developmental Biology
    2. Evolutionary Biology

    Architecture and evolution of the cis-regulatory system of the echinoderm kirrelL gene

    Jian Ming Khor, Charles A Ettensohn
    The transcriptional control system of a sea urchin gene reveals the deep evolutionary conservation of a gene regulatory network underlying morphogenesis.

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