Multicellular and socially aggregating prokaryotes contain previously undescribed, chaperone-based systems predicted to mediate defensive biological conflicts, several components of which are thematically similar antecedents of eukaryotic apoptosis pathways.
Robert J Bastidas, Mateusz Kędzior ... Raphael H Valdivia
Genetic and biochemical analyses show that Chlamydia protects secreted effectors necessary for its exit from infected cells, preventing them from undergoing ubiquitination and degradation.
Alon Avraham Ginatt, Maria Berihu ... Shiri Freilich
Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.
Arne Weinhold, Elham Karimi Dorcheh ... Ian T Baldwin
The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
Increasing the intra-species phenotypic diversity of a plant-beneficial bacterium effectively improves probiotic consortium functioning and plant growth promotion in agricultural systems.
A transport mechanism is uncovered in the major drug-efflux system in E. coli involving two remote alternating-access conformational cycles, which could provide the basis for the development of allosteric inhibitors against multidrug resistance.
Mark McMullan, Anastasia Gardiner ... Jonathan DG Jones
Hybridization and introgression blur species boundaries and broaden genetic diversity available for adaptation; and widespread introgression underpins the evolution of races of the generalist pathogen Albugo candida that specialise on different host plant species.
A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.
A novel bioinformatic pipeline predicts diverse pyoverdine structures and receptor groups with high accuracy, revealing significant hidden diversity in siderophores systems across Pseudomonas genomes.