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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An analog to digital converter controls bistable transfer competence development of a widespread bacterial integrative and conjugative element

    Nicolas Carraro, Xavier Richard ... Jan Roelof van der Meer
    A new multistep hierarchical cascade controls activation of an integrative and conjugative element in a small subpopulation of cells in its bacterial host, yielding proficient DNA transferring cells.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ParB spreading on DNA requires cytidine triphosphate in vitro

    Adam SB Jalal, Ngat T Tran, Tung BK Le
    A biochemical reconstitution shows that the accumulation of Caulobacter crescentus ParB on DNA requires cytidine triphosphate and a closed DNA substrate in vitro.
    1. Plant Biology

    A non canonical subtilase attenuates the transcriptional activation of defence responses in Arabidopsis thaliana

    Irene Serrano, Pierre Buscaill ... Susana Rivas
    An atypical subtilase protein, resulting from an alternative splicing event, mediates retention of the defence related-transcription factor MYB30 at endosomal vesicles, thus repressing Arabidopsis antibacterial immunity.
    1. Microbiology and Infectious Disease

    DNA Methylome Regulates Virulence and Metabolism in Pseudomonas syringae

    Jiadai Huang, Fang Chen ... Xin Deng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

    Giulia Bandini, Sebastian Damerow ... Michael AJ Ferguson
    The activity, localization, and essentiality of TbFUT1, together with its ability to complement Leishmania parasites lacking the homologous gene, suggest the presence of an uncommon and conserved mitochondrial fucosylation pathway required for kinetoplastid parasites viability.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of the Helicobacter pylori Cag type IV secretion system

    Jeong Min Chung, Michael J Sheedlo ... Melanie D Ohi
    The Helicobacter pylori Cag T4SS has unique structural features, including unexpected symmetry mismatch between sub-complexes, with implications for protein secretion.
    1. Genetics and Genomics
    2. Plant Biology

    Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition

    Simon Snoeck, Bradley W Abramson ... Adam D Steinbrenner
    A plant immune receptor evolved recognition of caterpillar peptides through key molecular changes.
    1. Microbiology and Infectious Disease

    Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

    Michael J Sheedlo, Jeong Min Chung ... D Borden Lacy
    The structure of a Type IV secretion system provides a framework for understanding assembly of a protein-injection machine.
    1. Plant Biology

    Pathogen effectors and plant immunity determine specialization of the blast fungus to rice subspecies

    Jingjing Liao, Huichuan Huang ... Jean-Benoit Morel
    Specialized fungal pathogen populations infect rice varieties with contrasting immune systems co-cultivated in a traditional agro-system, indicating the relevance of crop diversity to restricting epidemics in the landscape.