727 results found
  1. Episode 60: September 2019

    In this episode we hear about how sex makes female bees go blind, the cost of unnecessary medical procedures, how birds can fly over the Himalayas, an eLife author's trip to space and more.
  2. Picture of the bat Artibeus watsonii

    Episode 54: February 2019

    In this episode, we hear about colour vision in bats, frog vocal systems, ageing, problematic cell lines and how larger neurons could lead to a higher IQ.
  3. Ion channels: A Collection of Articles

    Edited by Kenton J Swartz et al.
    eLife has published papers on topics related to the molecular structure and functional mechanisms of a diverse array of ion channel proteins.
    1. Immunology and Inflammation

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al.
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

    Sandip Basak et al.
    Cryo-electron microscopic structures of 5-HT3A receptor in complex with first and second generations of clinically used setron reveal the molecular basis for their binding modes and mechanisms of inhibitory action.
    1. Microbiology and Infectious Disease

    An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis

    Angelika Jochim et al.
    An ECF-type transporter serves as broad-spectrum heme iron scavenger and allows an opportunistic pathogen to use multiple eukaryotic hemoproteins to overcome nutritional iron-limitation.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet et al.
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

    Juraj Ahel et al.
    RNF213 is a giant E3 ligase with a dynein-like core and a unique ubiquitination mechanism that proceeds in a RING-independent manner and is linked with the Moyamoya disease.
    1. Medicine

    Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge

    Anirban Sinha et al.
    Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
    1. Developmental Biology

    Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

    Xiaobo Wang et al.
    Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.

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