539 results found
    1. Genetics and Genomics

    Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes

    Shuai Zhang, Ruixue Wang ... Lin Sun
    Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
    1. Neuroscience

    Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

    Astrid Rollenhagen, Akram Sadeghi ... Joachim HR Lübke
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine

    A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model

    Mitsuru Sugimoto, Tadayuki Takagi ... Hiromasa Ohira
    A PEP risk scoring model that could be calculated before ERCP, SuPER model, may aid in preventing PEP by allowing selection of the appropriate expert endoscopist and useful PEP prophylaxes.
    1. Genetics and Genomics

    3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

    Khanh B Trang, Matthew C Pahl ... Struan FA Grant
    Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.
    1. Cell Biology

    Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

    Joan Chang, Adam Pickard ... Karl E Kadler
    Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
    1. Microbiology and Infectious Disease

    Capsular polysaccharide restrains type VI secretion in Acinetobacter baumannii

    Nicolas Flaugnatti, Loriane Bader ... Melanie Blokesch
    Capsular polysaccharides of Acinetobacter baumannii regulate type VI secretion system activity, balancing self-protection with interbacterial competitiveness.
    1. Medicine
    2. Neuroscience

    The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial

    Gansheng Tan, Anna L Huguenard ... Eric C Leuthardt
    Transcutaneous auricular vagus nerve stimulation is a safe neuromodulatory treatment for subarachnoid hemorrhage patients, with potential benefits for restoring autonomic balance.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Atlas of Fshr expression from novel reporter mice

    Hongqian Chen, Hui-Qing Fang ... Peng Liu
    Exploiting the power of the Fshr reporter, the first comprehensive genetic record of the spatial distribution of FSHR expression offers prospects for extensive exploration of FSH-FSHR biology.

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