580 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick
    Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
    1. Neuroscience

    Stimulus-dependent relationships between behavioral choice and sensory neural responses

    Daniel Chicharro, Stefano Panzeri, Ralf M Haefner
    New stimulus-dependencies of choice-related signals in sensory neurons uncovered by new analytical results and methods.
    1. Neuroscience

    Impaired voice processing in reward and salience circuits predicts social communication in children with autism

    Daniel Arthur Abrams, Aarthi Padmanabhan ... Vinod Menon
    Children with autism often 'tune out' the voices in their environment and new results show that impaired processing of voices in the brain's reward system may underlie this social behavior.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen, Anders S Hansen ... Xavier Darzacq
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Developmental Biology
    2. Genetics and Genomics

    Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

    Gang Zhai, Tingting Shu ... Zhan Yin
    Augmentation of progestin signaling promotes testis development and spermatogenesis independent from andorgen signaling in zebrafish.
    1. Microbiology and Infectious Disease

    Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

    Yang Meng, Yue Ni ... Chen Ding
    Isw1 acts as a master regulator in modulating the expression of drug-resistance genes, and this regulatory mechanism is dependent on the interaction of Isw1 acetylation and ubiquitination.
    1. Cell Biology

    Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors

    Dawei Wang, Zuodong Ye ... Jianbo Yue
    CapZ controls actin filament density around immature early endosomes via its C-terminal domain to facilitate the homotypic fusion of the endocytic vesicles, and it functions as a scaffold protein via its N-terminal domain to recruit RAB5 effectors to early endosomes.
    1. Neuroscience

    Salivary and plasmatic oxytocin are not reliable trait markers of the physiology of the oxytocin system in humans

    Daniel Martins, Anthony S Gabay ... Yannis Paloyelis
    Single measurements of baseline salivary and plasmatic oxytocin are not sufficiently reliable to provide valid trait markers of the physiology of the oxytocin system in humans.
    1. Developmental Biology
    2. Neuroscience

    Molecular characterization of cell types in the squid Loligo vulgaris

    Jules Duruz, Marta Sprecher ... Simon G Sprecher
    Single-cell transcriptomics correlated with in situ gene expression analysis provide an overview of the diversity and molecular features of cell types in the squid Loligo vulgaris.

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