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The study of the interactions between 65,356 variants of the SARS-CoV-2 receptor binding domain and a panel of monoclonal antibodies shows that Omicron’s escape is driven by a small number of large effect mutations.

The functional differences between actin isoforms have been explored through structural studies.

X-ray crystallography reveals how kinesin-1 recognises a novel class of cargo adaptor motifs in an isoform-specific manner.

The core autophagy protein Atg8 plays non-autophagy roles through binding to an integral membrane protein Hfl1, which harbors an unusual Atg8-interacting motif.

Unbiased proteomics and molecular analysis revealed a new role for S6K1 in regulating DNA repair through the orchestrated phosphorylation of CDK1 and MSH6. The findings may explain why RPS6KB1 gene amplification contributed to breast cancer drug resistance.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

Computer simulations explore the experimentally unknown S-protein structures, revealing novel drug binding sites.

Spatiotemporal manipulations of insomniac reveal that this gene regulates the birth and development of sleep-regulatory neurons, enabling their proper function in adulthood.

A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.