217 results found
    1. Stem Cells and Regenerative Medicine

    Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

    Lucy LeBlanc et al.
    During ES cell differentiation, Yap1 directly regulates apoptosis-related genes like Bcl-2 and Mcl-1 to attenuate apoptosis and promote cell survival to allow for successful cell fate changes.
    1. Plant Biology

    Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii

    Setsuko Wakao et al.
    SAK1, a novel cytoplasmic phosphoprotein, is a key intermediate component of the retrograde signaling pathway controlling nuclear gene expression during acclimation of Chlamydomonas cells to singlet oxygen stress.
    1. Developmental Biology

    Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

    Sobhika Agarwala et al.
    The cell junction-associated protein Amotl2a controls tissue size in the zebrafish lateral line primordium by limiting the activity of the Hippo effector Yap1 and the Wnt effector Lef1.
    1. Developmental Biology

    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

    David Kimelman et al.
    Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.
    1. Cell Biology

    Pak1 kinase controls cell shape through ribonucleoprotein granules

    Joseph O Magliozzi, James B Moseley
    A newly discovered substrate of Pak1 kinase reveals novel mechanisms that control cell shape through regulated assembly of ribonucleoprotein granules.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

    Alexander Muir et al.
    TORC2-Ypk1 signaling upregulates flux through the sphingolipid pathway not only by increasing the supply of long-chain base precursors, but also by increasing their use in synthesizing complex sphingolipids.
    1. Cancer Biology
    2. Cell Biology

    p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

    Pauline Jeannot et al.
    p27Kip1 directly controls invadopodia turnover by promoting the interaction of PAK1 with Cortactin, which induces Cortactin phosphorylation, invadopodia disassembly and facilitates invasion through extracellular matrix.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion

    Viktoria Désirée Paul et al.
    Two newly identified assembly factors for the ribosome-associated iron-sulfur protein Rli1 reveal a general mechanism for how the cytosolic iron-sulfur protein assembly (CIA) machinery recruits apoproteins.
    1. Cell Biology

    Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

    Yajuan Guo et al.
    Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
    1. Cell Biology
    2. Developmental Biology

    YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

    Kishor K Sivaraj et al.
    The interplay between the transcriptional co-regulators YAP1/TAZ and the hypoxia-controlled transcription factor HIF1α differentially regulates endothelial cell behavior in the hypoxic environment of bone compared to other organs.

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