The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
Genetic study of C. elegans neural development reveals the function of glia-neuron gap junctions in neuronal axon specification, and shows that glial cells regulate neuronal intracellular pathways through gap junctions.
Protein heptosyltransferases modify a group of bacterial autotransporters for virulence function and employ a novel structural mechanism for the processive hyperglycosylation of the autotransporter.
A high-throughput technique to characterize the substrate specificities of tyrosine kinases identifies the key features of kinases and substrates that enforce accurate signaling from T cell receptors.
The deletion of a single gene encoding a selective bile salt hydrolase from the abundant human gut bacterium Bacteroides thetaiotaomicron significantly alters host metabolism.
Gap junctions exist in Kenyon cells and Kenyon cell-mushroom body output neuron neural networks, and are also critical in visual learning and memory in Drosophila.
The N-terminus of the FGF14b isoform promotes the inactivation of voltage-gated Na+ channels to regulate the resurgent Na+ channel current needed for high frequency action potentials.
The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.
