6,371 results found
    1. Developmental Biology

    YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

    Chuwen Lin et al.
    The control of local cell properties such as epithelial cell number and mechanical force production by Hippo signaling is a major determinant of lung branching.
    1. Neuroscience

    Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans

    Lingfeng Meng et al.
    Genetic study of C. elegans neural development reveals the function of glia-neuron gap junctions in neuronal axon specification, and shows that glial cells regulate neuronal intracellular pathways through gap junctions.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family

    Qing Yao et al.
    Protein heptosyltransferases modify a group of bacterial autotransporters for virulence function and employ a novel structural mechanism for the processive hyperglycosylation of the autotransporter.
    1. Developmental Biology

    The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

    Aleksander D Szymaniak et al.
    The transcriptional regulator YAP directs the specification and differentiation of stem cells that give rise to salivary gland ductal epithelium.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

    Neel H Shah et al.
    A high-throughput technique to characterize the substrate specificities of tyrosine kinases identifies the key features of kinases and substrates that enforce accurate signaling from T cell receptors.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A selective gut bacterial bile salt hydrolase alters host metabolism

    Lina Yao et al.
    The deletion of a single gene encoding a selective bile salt hydrolase from the abundant human gut bacterium Bacteroides thetaiotaomicron significantly alters host metabolism.
    1. Developmental Biology

    Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

    Zhian Ye et al.
    Atoh1+ HC precursors survive post severe injury and activate the Yap-Lin28 pathway to restore progenitor for initiating regeneration.
    1. Neuroscience

    Gap junction networks in mushroom bodies participate in visual learning and memory in Drosophila

    Qingqing Liu et al.
    Gap junctions exist in Kenyon cells and Kenyon cell-mushroom body output neuron neural networks, and are also critical in visual learning and memory in Drosophila.
    1. Neuroscience

    FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons

    Haidun Yan et al.
    The N-terminus of the FGF14b isoform promotes the inactivation of voltage-gated Na+ channels to regulate the resurgent Na+ channel current needed for high frequency action potentials.
    1. Structural Biology and Molecular Biophysics

    Structural model for differential cap maturation at growing microtubule ends

    Juan Estévez-Gallego et al.
    The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.

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