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    1. Neuroscience

    Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1

    Amy M LeMessurier et al.
    Sensory enrichment creates a more columnar, less salt-and-pepper whisker map in somatosensory cortex, showing that impoverished experience contributes to intermixed tuning in rodent sensory maps.
    1. Developmental Biology

    The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

    Aleksander D Szymaniak et al.
    The transcriptional regulator YAP directs the specification and differentiation of stem cells that give rise to salivary gland ductal epithelium.
    1. Cancer Biology
    2. Cell Biology

    Regulation of localization and function of the transcriptional co-activator YAP by angiomotin

    Susana Moleirinho et al.
    Phosphorylation of Angiomotin regulates YAP localization and activity.
    1. Developmental Biology

    Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

    Sobhika Agarwala et al.
    The cell junction-associated protein Amotl2a controls tissue size in the zebrafish lateral line primordium by limiting the activity of the Hippo effector Yap1 and the Wnt effector Lef1.
    1. Plant Biology

    A novel role for the root cap in phosphate uptake and homeostasis

    Satomi Kanno et al.
    Real-time 33P imaging combined with specific complementation of inorganic phosphate transport in the root cap reveals this tissue’s contribution to phosphate uptake.
    1. Neuroscience

    Mouse rods signal through gap junctions with cones

    Sabrina Asteriti et al.
    Electrophysiological recordings show that cones in the eyes of mice are able to receive strong input from rods via gap junctions, supporting the view that this route plays an important role in vision.
    1. Neuroscience

    An extended retinotopic map of mouse cortex

    Jun Zhuang et al.
    An expanded map of mouse cortex reveals the expansion of retinotopic organization into barrel and retrosplenial cortices.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish

    Uwe Irion et al.
    Melanophores and xanthophores interact via heteromeric gap junctions composed of Connexin 41.8 and Connexin 39.4 to establish the adult pigment pattern in zebrafish.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

    Yuxiao Wang et al.
    The crystal structures of the intracellular part of the plexin receptor in the active dimer form, and its complex with a key downstream signalling protein Rap, provide insights into how plexin initiates a signalling cascade involved in axon guidance.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

    Roni M Lahr et al.
    La-related protein 1 specifically and directly binds the 5' cap and first nucleotide of mRNAs encoding ribosomal proteins and translation factors, inhibiting the assembly of translation initiation factors on these messages and therefore their translation.