10,828 results found
    1. Cell Biology
    2. Neuroscience

    Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model

    Nuria Martin Flores, Marina Podpolny ... Patricia C Salinas
    The Wnt antagonist DKK3 is a key regulator of excitatory and inhibitory synapses, and its downregulation in the hippocampus restores synaptic connectivity and memory in an Alzheimer's disease mouse model.
    1. Neuroscience

    Mating activates neuroendocrine pathways signaling hunger in Drosophila females

    Meghan Laturney, Gabriella R Sterne, Kristin Scott
    Postmated increases in sucrose consumption in Drosophila melanogaster females is executed by a female specific circuit that alters neuroendocrine centers to promote hunger.
    1. Immunology and Inflammation

    Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells

    Anders Laustsen, Renée M van der Sluis ... Rasmus O Bak
    Probing of various culture conditions leads to fundamental advances in ex vivo production of plasmacytoid dendritic cells for use in immunotherapy.
    1. Neuroscience

    Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

    Amanda J González Segarra, Gina Pontes ... Kristin Scott
    A peptidergic network translates internal nutrient abundance cues into the coordinated regulation of sugar and water ingestion.
    1. Neuroscience

    A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

    Yishan Sun, Sergiu P Paşca ... Ricardo E Dolmetsch
    A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
    1. Stem Cells and Regenerative Medicine

    Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

    Justinn Barr, Maria Elena Gentile ... Andrew E Vaughan
    Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.
    1. Cell Biology

    In vitro reconstitution of branching microtubule nucleation

    Ammarah Tariq, Lucy Green ... James G Wakefield
    Purification of two conserved protein complexes, the γ-TuRC and Augmin, using a simple affinity technique, demonstrates that they are necessary and sufficient for the essential phenomenon of branching microtubule nucleation.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

    Robin A Corey, Zainab Ahdash ... Ian Collinson
    How the process of protein folding may be controlled by the Sec machinery to assist protein transport across membranes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

    Ahmed Rattani, Magda Wolna ... Kim Nasmyth
    Shugoshin-like protein 2 (Sgol2) is involved in a variety of cell cycle process during the first stage of meiotic division.
    1. Developmental Biology
    2. Plant Biology

    Coordination of tissue cell polarity by auxin transport and signaling

    Carla Verna, Sree Janani Ravichandran ... Enrico Scarpella
    GNOM controls both auxin transport and auxin signaling to coordinate tissue cell polarity during vein patterning in plants.

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