Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.
Functional analyses of in vitro fertilized, preimplanation human embryos reveal that the first lineage segregation depends on cell polarization signaling that is regulated by Phospholipase C (PLC) activity.
The nervous system can learn to control standing balance with added sensorimotor delays by causally linking delayed whole-body sensory feedback, initially deemed as unexpected, to self-generated balance motor commands.
The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.