393 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage

    Shun-Hsiao Lee, Lissa Nicola Princz ... Christian Biertümpfel
    The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.
    1. Chromosomes and Gene Expression

    The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes

    Keith Conrad Fernandez, Laura Feeney ... Jayanta Chaudhuri
    A novel conditional mouse model to interrogate the requirements of structure-selective endonucleases in the development, functionality, and genome stability of B lymphocytes.
    1. Cell Biology

    Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

    Chia-An Yen, Dana L Ruter ... Sean P Curran
    Loss of FAD stemming from cell autonomous defects in mitochondrial proline catabolism impairs sperm quality male reproductive advantage in C. elegans.
    1. Computational and Systems Biology
    2. Neuroscience

    Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans

    Hongfei Ji, Anthony D Fouad ... Christopher Fang-Yen
    Behavioral, optogenetic, and computational modeling analyses show that the roundworm Caenorhabditis elegans uses a relaxation oscillation mechanism to generate rhythmic locomotor patterns.
    1. Neuroscience

    Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion

    Anthony D Fouad, Shelly Teng ... Christopher Fang-Yen
    The forward locomotor circuit of the roundworm Caenorhabditis elegans consists of multiple rhythm-generating units coupled to one another in a bidirectional manner.
    1. Developmental Biology
    2. Neuroscience

    Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

    Ya-Ping Yen, Wen-Fu Hsieh ... Jun-An Chen
    LncRNAs are important to stabilize postmitotic cell fate of spinal motor neurons.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

    Matthew A Churgin, Sang-Kyu Jung ... Christopher Fang-Yen
    The WorMotel, a novel microfabricated device for automated longitudinal imaging of aging in large numbers of Caenorhabditis elegans, reveals that long and short lived strains vary in their behavioral decline during aging in a similar way to the long and short lived individuals in a wild type population.
    1. Microbiology and Infectious Disease

    Evolutionary consequences of intra-patient phage predation on microbial populations

    Kimberley D Seed, Minmin Yen ... Andrew Camilli
    Bacterial viruses are an unexpected ‘third party’ that imposes a strong predatory pressure on a bacterial pathogen during the natural course of infection in humans.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

    Christopher John Schlicksup, Joseph Che-Yen Wang ... Adam Zlotnick
    Small molecule antivirals that drive assembly of HBV capsid protein can also bind to pre-assembled capsids causing them to change morphology or even break, suggesting a complex transduction of binding effects across the capsid.
    1. Neuroscience

    Minimally dependent activity subspaces for working memory and motor preparation in the lateral prefrontal cortex

    Cheng Tang, Roger Herikstad ... Shih-Cheng Yen
    The evidence of subspace computation in the lateral prefrontal cortex provides insights into the neural mechanisms underlying cognitive flexibility and interference between different cognitive processes.

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