97 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

    Megan Okada, Krithika Rajaram ... Paul A Sigala
    Malaria parasites target a polyprenyl synthase enzyme to the apicoplast organelle and require its activity to produce long-chain linear isoprenoids necessary for apicoplast biogenesis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann, Rokas Grigaitis ... Boris Pfander
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.
    1. Microbiology and Infectious Disease

    Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins

    Leonor García-Bayona, Monica S Guo, Michael T Laub
    Genetic, biochemical, and cell biological approaches reveal a new form of contact-dependent inhibition in bacteria involving bacteriocin-like proteins that aggregate on the surface of cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal, Paola Nol Bernadino ... Emily P Balskus
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

    Noah M Dietzen, Mark J Arcario ... Wayland WL Cheng
    Docosahexaenoic acid (DHA) inhibits ELIC through state-dependent binding to a single site.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Identification of a pre-active conformation of a pentameric channel receptor

    Anaïs Menny, Solène N Lefebvre ... Pierre-Jean Corringer
    Allosteric reorganizations of a bacterial channel receptor are mapped along the protein structure, using the site-directed bimane quenching fluorescence technique, through parallel real-time conformational and electrophysiological recordings.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A secreted Ustilago maydis effector promotes virulence by targeting anthocyanin biosynthesis in maize

    Shigeyuki Tanaka, Thomas Brefort ... Regine Kahmann
    A fungal effector secreted by the corn smut pathogen increases the virulence of the pathogen by elevating anthocyanin production and reducing lignification in maize.
    1. Ecology
    2. Evolutionary Biology

    Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form of Cacopsylla chinensis

    Zhixian Zhang, Jianying Li ... Songdou Zhang
    Integrated ecological and genetic methods show that Bursicon signaling pathway and miR-6012 regulate the transition from summer-form to winter-form in Cacopsylla chinensis through affecting cuticle pigment and cuticle thickness.
    1. Ecology
    2. Evolutionary Biology

    miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

    Songdou Zhang, Jianying Li ... Xiaoxia Liu
    The first comprehensive study on the regulation mechanism of miR-252 and temperature receptor CcTRPM on insect seasonal polyphenism will also conducive to designing a new method for pest control.
    1. Plant Biology

    A fungal member of the Arabidopsis thaliana phyllosphere antagonizes Albugo laibachii via a GH25 lysozyme

    Katharina Eitzen, Priyamedha Sengupta ... Gunther Doehlemann
    A basidiomycete yeast closely related to fungal smuts is an antagonistic microbe in the Arabidopsis leaf phyllosphere that inhibits infection by Albugo laibachii via a GH25 hydrolase with lysozyme activity.

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