27 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A structural model of the active ribosome-bound membrane protein insertase YidC

    Stephan Wickles et al.
    A cryo-EM structure combined with bioinformatics provide a structural view on a conserved co-translational membrane protein biogenesis pathway.
    1. Structural Biology and Molecular Biophysics

    Insights into the ubiquitin transfer cascade catalyzed by the Legionella effector SidC

    David Jon Wasilko et al.
    Structural and biochemical studies reveal the molecular mechanisms for ubiquitin transfer by two unique bacterial ubiquitin E3 ligases.
    1. Cell Biology

    Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

    Yidi Sun et al.
    Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM interaction network which gives actin assembly onset a switch-like behavior in vivo.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al.
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Regulation of multispanning membrane protein topology via post-translational annealing

    Reid C Van Lehn et al.
    Coarse-grained modeling reveals a new mechanism for multispanning membrane protein topogenesis, in which misintegrated configurations of the proteins undergo post-translational annealing to reach final, fully integrated multispanning topologies.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation

    Nikola Ojkic et al.
    Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.
    1. Cell Biology

    The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

    Matthew J Shurtleff et al.
    The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai et al.
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

    Paul Victor Sauer et al.
    The CAF1 complex binds single histone H3-H4 dimers, and two such complexes associate with extended DNA elements to ensure the deposition of H3-H4 tetramers, the first step in the assembly of nucleosomes.
    1. Structural Biology and Molecular Biophysics

    Architecture of the human mTORC2 core complex

    Edward Stuttfeld et al.
    The structure of the mammalian target of rapamycin complex 2 (mTORC2) reveals the architecture of the complex and explains the structural basis of rapamycin insensitivity.

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